Endocrine Abstracts

Introduction: The prevalence of primary hyperparathyroidism is increasing owing to the more the routinely measurements of serum calcium. A single benign para-thyroid adenoma is the most frequent cause of sporadic PHPT. Primary hyperparathyroidism can also be due to ectopic mediastinal parathyroid adenoma in 11-25% of patients, more frequently involving inferior parathyroid translated in anterior mediastinum. In general to detect ectopic adenoma recent guidelines recommend the ...

Background: Familial isolated pituitary adenomas (FIPA) is a rare inherited disorder accounting for about 2% of pituitary adenomas. Mutations in the Aryl hydrocarbon receptor Interacting Protein (AIP) gene have been described in about 15% of FIPA families and rarely in early onset sporadic pituitary adenomas. Among the AIP mutations reported so far, the R304X represents, after the Finnish founder mutation Q14X, the second most common one.Me...

Aim: This guideline (GL) is aimed at providing a reference for the management of prolactin (PRL)-secreting pituitary adenoma in non-pregnant adults.Methods: For each question, the panel identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices.Results: The present GL provides recommendations about the roles of pharmacological and neurosurgical treatment for the management of prolactinom...